Regulation of the Autophagic Bcl-2/Beclin 1 Interaction

Cells

Jean-Paul Decuypere¹  Jan B. Parys² 

[1] Laboratory of Molecular and Cellular Signaling, Department of Cellular and Molecular Medicine, KU Leuven, O/N-1, bus 802, Herestraat 49, Leuven, BE-3000, Belgium;

关键词: autophagy;    Bcl-2;    Bcl-X_L;    Mcl-1;    Beclin 1;    JNK1;    DAPK;    IP₃R;    Naf-1;    BH3 mimetics;   

DOI  :  10.3390/cells1030284

来源: mdpi

【 摘 要 】

Autophagy is an intracellular degradation process responsible for the delivery of cellular material to the lysosomes. One of the key mechanisms for control of autophagy is the modulation of the interaction between the autophagic protein Beclin 1 and the members of the anti-apoptotic Bcl-2 family (e.g., Bcl-2, Bcl-X_L and Mcl-1). This binding is regulated by a variety of proteins and compounds that are able to enhance or inhibit the Bcl-2/Beclin 1 interaction in order to repress or activate autophagy, respectively. In this review we will focus on this interaction and discuss its characteristics, relevance and regulation.

【 授权许可】

CC BY   
© 2012 by the authors; licensee MDPI, Basel, Switzerland.