Anti-Inflammatory and Analgesic Activity of Total Flavone of Cunninghamia lanceolata

Molecules

Hai-Liang Xin¹  Xiao-Feng Zhai¹  Xu Zheng¹  Lei Zhang¹  Yu-Liang Wang¹ 

[1] ¹Department of Traditional Chinese Medicine, Changhai Hospital, Second Military Medical University, Shanghai 200433, China

关键词: Cunninghamia lanceolata (Lamb.) Hook;    total flavone;    anti-inflammatory;    analgesia;   

DOI  :  10.3390/molecules17088842

来源: mdpi

【 摘 要 】

The present study was undertaken to investigate the anti-inflammatory and analgesic activity of total flavone of branches and leaves of Cunninghamia lanceolata (TFC) to provide a scientific basis for its clinical use and resource development. TFC was evaluated for anti-inflammatory and analgesic activity in mice or rats using chemical and thermal models of nociception, including acetic acid-induced writhing test, hot plate latency test, formalin test and carrageenan induced paw oedema test. Results showed that TFC given orally can significantly attenuate acetic acid-induced writhing in mice in a dose-dependent manner. In the hot plate latency test, TFC showed common activity in prolonging duration time only at the highest dose (400 mg/kg). Each dose of TFC could not significantly inhibit the first phase but was active in the later phase of formalin-induced pain, whereas morphine showed notable activity in the two phases. In the carrageenan-induced paw oedema model, TFC could significantly and dose-dependently reduce the carrageenan-induced paw edema at the third and fifth hour, and decrease the content of PEG₂ in paw edema tissue and that of COX-2 in blood serum. It may be concluded that TFC showed both anti-inflammatory and analgesic effects, showing that it can be of importance in drug development, especially in the field of pain and inflammation.

【 授权许可】

CC BY   
This is an open access article distributed under the Creative Commons Attribution License (CC BY) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.