Electrospray Ionization Mass Spectrometric Analysis of Highly Reactive Glycosyl Halides

Molecules

Attila Bokros¹  Annamária Bánfi¹  Zoltán Kupihár¹  Zoltán Kele¹  Tünde Zita Illyés¹  János Szolomájer¹ 

[1] ¹Department of Medicinal Chemistry, Faculty of Medicine, University of Szeged, Dóm tér 8, H-6720 Szeged, Hungary ²Department of Organic Chemistry, Faculty of Science and Technology, University of Debrecen, Egyetem tér 1, H-4010 Debrecen, Hungary

关键词: glycosyl halides;    electrospray mass spectrometry;    nanoelectrospray;    lithium salts;   

DOI  :  10.3390/molecules17078351

来源: mdpi

【 摘 要 】

Highly reactive glycosyl chlorides and bromides have been analysed by a routine mass spectrometric method using electrospray ionization and lithium salt adduct-forming agents in anhydrous acetonitrile solution, providing salient lithiated molecular ions [M+Li]⁺, [2M+Li]⁺ etc. The role of other adduct-forming salts has also been evaluated. The lithium salt method is useful for accurate mass determination of these highly sensitive compounds.

【 授权许可】

CC BY   
This is an open access article distributed under the Creative Commons Attribution License (CC BY) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.