Antifungal Activity, Toxicity and Chemical Composition of the Essential Oil of Coriandrum sativum L. Fruits

Molecules

Bruna V. Soares¹  Selene M. Morais¹  Raquel Oliveira dos Santos Fontenelle¹  Vanessa A. Queiroz¹  Nadja S. Vila-Nova¹  Christiana M. C. Pereira¹  Edy S. Brito¹  Manoel A. S. Neto¹  Erika H. S. Brito¹  Carolina S. P. Cavalcante¹  Débora S. C. M. Castelo-Branco¹ 

[1] ¹Postgraduate Program in Veterinary Sciences, State University of Ceará, 60740-000, Fortaleza, CE, Brazil

关键词: Coriandrum sativum;    essential oil;    Microsporum canis;    Candida spp.;    Artemia salina;    linalool;   

DOI  :  10.3390/molecules17078439

来源: mdpi

【 摘 要 】

The aims of this study were to test the antifungal activity, toxicity and chemical composition of essential oil from C. sativum L. fruits. The essential oil, obtained by hydro-distillation, was analyzed by gas chromatography/mass spectroscopy. Linalool was the main constituent (58.22%). The oil was considered bioactive, showing an LC₅₀ value of 23 µg/mL in the Artemia salina lethality test. The antifungal activity was evaluated against Microsporum canis and Candida spp. by the agar-well diffusion method and the minimum inhibitory concentration (MIC) and the minimum fungicidal concentration (MFC) were established by the broth microdilution method. The essential oil induced growth inhibition zones of 28 ± 5.42 and 9.25 ± 0.5 for M. canis and Candida spp. respectively. The MICs and MFCs for M. canis strains ranged from 78 to 620 and 150 to 1,250 µg/mL, and the MICs and MFCs for Candida spp strains ranged from 310 to 620 and 620 to 1,250 µg/mL, respectively. C. sativum essential oil is active in vitro against M. canis and Candida spp. demonstrating good antifungal activity.

【 授权许可】

CC BY   
This is an open access article distributed under the Creative Commons Attribution License (CC BY) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.