4-Methylenesterols from a Sponge Theonella swinhoei

Marine Drugs

Jheng-Kun Guo¹  Ching-Ying Chiang²  Mei-Chin Lu¹  Wen-Been Chang¹ 

[1] National Museum of Marine Biology & Aquarium, Pingtung 944, Taiwan;Center of General Studies, National Kaohsiung Marine University, Kaohsiung 811, Taiwan;

关键词: 4-methylenesterols;    sponge;    Theonella;   

DOI  :  10.3390/md10071536

来源: mdpi

【 摘 要 】

Three new 4-methylenesterols, theonellasterol K (1), acetyltheonellasterol (2) and acetyldehydroconicasterol (3), along with two known sterols, theonellasterol (4) and theonellasterone (5), were isolated from the sponge Theonella swinhoei. The structures of these compounds were elucidated on the basis of their spectroscopic data and comparison of the NMR data with those of known analogues. Compound 1 exhibited significant cytotoxic activity against HCT-116, K562 and Molt 4 cancer cell lines.

【 授权许可】

CC BY   
© 2012 by the authors; licensee MDPI, Basel, Switzerland.