Synthesis, Characterization, Antibacterial and Antifungal Evaluation of Novel Monosaccharide Esters

Molecules

Yi Shen¹  Yufeng Sun¹  Zhipei Sang¹  Chengjun Sun¹  Ya Dai¹ 

[1] ¹West China School of Public Health, Sichuan University, Chengdu 610041, China

关键词: carbohydrate-acetonides;    3-(2-furyl)acrylate monosaccharide esters;    menthyloxycarbonyl monosaccharide esters;    antibacterial activities;    antifungal activities;   

DOI  :  10.3390/molecules17078661

来源: mdpi

【 摘 要 】

A novel series of 3-(2-furyl)acrylate monosaccharide esters Ia–f and menthyloxycarbonyl monosaccharide esters IIa–f were designed and synthesized. The chemical structures of the target compounds were confirmed by IR, ¹H- and ¹³C-NMR and ESI-MS, and the target compounds were investigated for their in vitro antibacterial and antifungal activities. The antibacterial screening results showed that the 3-(2-furyl)acrylate monosaccharide ester derivatives Ia–f were either inactive or only weakly active against the three Gram-positive bacterial strains tested, whereas the menthyloxycarbonyl monosaccharide ester derivatives IIa–f exhibited higher levels of activity, with compound IIe being especially potent. The results of the antifungal screening revealed that compounds Ib, Ie, IIb and IIc displayed potent in vitro activities, whereas If and IIf showed promising activities against all of the microorganisms tested, with If exhibiting levels of activity deserving of further investigation.

【 授权许可】

CC BY   
This is an open access article distributed under the Creative Commons Attribution License (CC BY) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.