Correlation among Antioxidant, Antimicrobial, Hemolytic, and Antiproliferative Properties of Leiothrix spiralis Leaves Extract

International Journal of Molecular Sciences

Marcelo Gonzaga de Freitas Araújo²  Felipe Hilário⁴  Wagner Vilegas⁴  Lourdes Campaner dos Santos⁴  Iguatemy Lourenço Brunetti¹  Claudia Elena Sotomayor³ 

[1] Clinical Analysis Department, Faculty of Pharmaceutical Sciences, São Paulo State University—UNESP, Araraquara, SP 14801-902, Brazil; E-Mail:;Biological Sciences Department, Faculty of Pharmaceutical Sciences, São Paulo State University—UNESP, Araraquara, SP 14801-902, Brazil; E-Mail:;Department of Clinical Biochemistry, CIBICI-CONICET, Faculty of Chemical Sciences, National University of Cordoba, Haya de la Torre y Medina Allende, Córdoba 5000, Argentina; E-Mail:;Organic Chemistry Department, Chemistry Institute, São Paulo State University—UNESP, c.p. 355, Araraquara, SP 14800-900, Brazil; E-Mails:

关键词: Leiothrix spiralis;    luteolin;    antioxidant;    antimicrobial;    hemolytic;    citotoxicity;   

DOI  :  10.3390/ijms13079260

来源: mdpi

【 摘 要 】

The biological activities of a plant extract depend on a complex sum of individual properties including the antioxidant activity. Several biological activities protect against the harmful action of reactive oxygen species (ROS), and here we focused our attention on the relationship between the biological activities tested and the antioxidant properties. In this study, the total flavonoid content as well as the antioxidant, antimicrobial, hemolytic and cytotoxicity activities of the methanolic extract of Leitothrix spiralis leaves were evaluated. The extract showed a total flavonoid content of 19.26% and the chemical characterization by HPLC-PAD confirmed the presence of flavonoids as the major secondary metabolite compounds. Significant antioxidant activity (IC₅₀ = 1.743 μg/mL ± 0.063) was demonstrated and was effective against Gram-negative organisms and all Candida strains tested, and showed an ability to inhibit hyphal formation. Non-hemolytic and antiproliferative activity could be demonstrated.

【 授权许可】

CC BY   
© 2012 by the authors; licensee Molecular Diversity Preservation International, Basel, Switzerland.