Acuminatol and Other Antioxidative Resveratrol Oligomers from the Stem Bark of Shorea acuminata

Molecules

Norhayati Muhammad⁴  Laily B. Din⁴  Idin Sahidin³  Siti Farah Hashim¹  Nazlina Ibrahim¹  Zuriati Zakaria² 

[1] School of Biosciences and Biotechnology, Faculty of Science and Technology, Universiti Kebangsaan Malaysia, UKM Bangi 43600, Selangor D.E., Malaysia;Malaysia-Japan International Institute of Technology, Universiti Teknologi Malaysia Kuala Lumpur, Jalan Semarak, Kuala Lumpur 54100, Malaysia;Faculty of Mathematics and Natural Sciences, Haluoleo University, Kendari 93232, Sulawesi Tenggara, Indonesia;School of Chemical Sciences and Food Technology, Faculty of Science and Technology, Universiti Kebangsaan Malaysia, UKM Bangi 43600, Selangor D.E., Malaysia;

关键词: Dipterocarpaceae;    Shorea acuminata;    resveratrol oligomer;    acuminatol;    antioxidant activity;    cytotoxicity;   

DOI  :  10.3390/molecules17089043

来源: mdpi

【 摘 要 】

A new resveratrol dimer, acuminatol (1), was isolated along with five known compounds from the acetone extract of the stem bark of Shorea acuminata. Their structures and stereochemistry were determined by spectroscopic methods, which included the extensive use of 2D NMR techniques. All isolated compounds were evaluated for their antioxidant activity using the 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical scavenging activity (RSA) and the β-carotene-linoleic acid (BCLA) assays, and compared with those of the standards of ascorbic acid (AscA) and butylated hydroxytoluene (BHT). All compounds tested exhibited good to moderate antioxidant activity in the DPPH assay (IC₅₀s 0.84 to 10.06 mM) and displayed strong inhibition of β-carotene oxidation (IC₅₀s 0.10 to 0.22 mM). The isolated compounds were evaluated on the Vero cell line and were found to be non-cytotoxic with LC₅₀ values between 161 to 830 µM.

【 授权许可】

CC BY   
© 2012 by the authors; licensee MDPI, Basel, Switzerland.