Evaluation of the Pharmacological Function of Ulinastatin in Experimental Animals

Molecules

Chong-En Xu²  Meng-Yuan Zhang¹  Cheng-Wei Zou² 

[1] Department of Anesthesia, Provincial Hospital Affiliated to Shandong University, 324# Jingwu-Weiqi Road, Jinan, 250021, China;Department of Cardiac Surgery, Provincial Hospital Affiliated to Shandong University, 324# Jingwu-Weiqi Road, Jinan, 250021, China

关键词: oxidative injury;    SOD;    ulinastatin;    AST;    LDH;    NO;   

DOI  :  10.3390/molecules17089070

来源: mdpi

【 摘 要 】

Organ protection is a routine therapy in severe injuries. Our aim was to evaluate the beneficial effects of ulinastatin in experimental rats. Rats were randomly divided into a sham control, a model control and an ulinastatin-treated group. Malondialdehyde (MDA) and superoxide dismutase (SOD) levels were determined. Serum amylase, serum aspartate aminotransaminase (AST), lactate dehydrogenase (LDH) and creatine kinase isoenzyme (CKMD) activities, interleukin-8 (IL-8), tumor necrosis factor-α (TNF-α), nitric oxide (NO) and cardiac troponin I (nTnl) levels were examined. Results showed that ulinastatin decreased MDA levels and ameliorated the down-regulation of SOD activity. In addition, ulinastatin pretreatment may decrease serum AST, LDH and CKMD activities, IL-8, TNF-α, and nTnl levels, and enhance NO level. Our results demonstrated that oxidative injury occurred after IR and that ulinastatin exhibits significant protective effects against these effects.

【 授权许可】

CC BY   
© 2012 by the authors; licensee MDPI, Basel, Switzerland.