Diterpenoids from the Buds of Pinus banksiana Lamb.

Molecules

Patricia Georges¹  Jean Legault¹  Serge Lavoie¹  Carole Grenon¹ 

[1] Laboratoire d'analyse et de séparation des essences végétales, Département des sciences fondamentales, Chaire de recherche sur les agents anticancéreux d'origine naturelle, Université du Québec à Chicoutimi, Québec, G7H 2B1 Canada;

关键词: Pinus banksiana;    bud;    dehydroabietane;    cytotoxicity;    antibacterial activity;   

DOI  :  10.3390/molecules17089716

来源: mdpi

【 摘 要 】

Three new diterpenoids, namely 7α-hydroxyabieta-8,11,13,15-tetraen-18-oic acid, 7β,15,18-trihydroxyabieta-8,11,13-triene, 13,15-dihydroxypodocarpa-8,11,13-triene, and 12 other known compounds were isolated from buds of Pinus banksiana Lamb. All these compounds, except for 7-oxodehydroabietinol, were isolated for the first time from this plant. Their structures were elucidated by detailed spectroscopic studies and comparison with published data. All isolated compounds were tested for cytotoxic and antibacterial activities. Overall, two compounds, 7-oxodehydroabietinol and 18-nor-4,15-dihydroxyabieta-8,11,13-trien-7-one, showed moderate cytotoxicity against a human lung carcinoma cell line.

【 授权许可】

CC BY   
© 2012 by the authors; licensee MDPI, Basel, Switzerland.