Melanogenesis Inhibition by Homoisoflavavone Sappanone A from Caesalpinia sappan

International Journal of Molecular Sciences

Te-Sheng Chang¹  Shih-Yu Chao¹ 

[1] Department of Biological Sciences and Technology, National University of Tainan, 33 sec. 2 Su-Lin St., Tainan 700, Taiwan; E-Mail:

关键词: Caesalpinia sappan;    inhibition;    melanogenesis;    sappanone A;    tyrosinase;   

DOI  :  10.3390/ijms130810359

来源: mdpi

【 摘 要 】

Homoisoflavanone, sappanone A, was isolated from Caesalpinia sappan and proven to dose-dependently inhibit both melanogenesis and cellular tyrosinase activity via repressing tyrosinase gene expression in mouse B16 melanoma cells. To our knowledge, sappanone A is the first homoisoflavanone to be discovered with melanogenesis inhibitory activity. Our results give a new impetus to the future search for other homoisoflavanone melanogenesis inhibitors.

【 授权许可】

CC BY   
© 2012 by the authors; licensee Molecular Diversity Preservation International, Basel, Switzerland.