Deciphering the Molecular Nature of Ovarian Cancer Biomarker CA125

International Journal of Molecular Sciences

Florian Weiland²  Karina Martin²  Martin K. Oehler¹ 

[1] Research Centre for Reproductive Health, Robinson Institute, University of Adelaide, Adelaide, SA 5005, Australia; E-Mail:;Adelaide Proteomics Centre, School of Molecular and Biomedical Science, University of Adelaide, Adelaide, SA 5005, Australia; E-Mails:

关键词: CA125;    MUC16;    ovarian cancer;    biomarker;    mass spectrometry;   

DOI  :  10.3390/ijms130810568

来源: mdpi

【 摘 要 】

The ovarian cancer biomarker CA125 has been extensively investigated over the last 30 years. The knowledge about the exact molecular nature of this protein, however, remains fragmented. This review provides an overview of the structural research regarding CA125, and presents an orthogonal verification method to confirm the identity of this molecule. The need for independent identification of CA125 is exemplified by several reports where mutually exclusive data concerning the existence of isoforms and the glycan moieties is presented. Mass spectrometry can overcome the pitfalls of a single detection/identification method such as antibody probing. Independent verification of CA125 identity in characterization studies will help establish a refined model of its molecular structure that will promote the development of new approaches for diagnosis, prognosis and therapy of ovarian cancer.

【 授权许可】

CC BY   
© 2012 by the authors; licensee Molecular Diversity Preservation International, Basel, Switzerland.