The Chemical Components of Sesbania grandiflora Root and Their Antituberculosis Activity

Pharmaceuticals

Noviany Hasan¹  Hasnah Osman¹  Suriyati Mohamad²  Keng Chong Wong¹  Khalijah Awang³ 

[1] School of Chemical Sciences, University of Science Malaysia, Minden 11800, Penang, Malaysia;School of Biological Sciences, University of Science Malaysia, Minden 11800, Penang, Malaysia;Department of Chemistry, Faculty of Science, University of Malaya, Kuala Lumpur 50603, Malaysia;

关键词: isovestitol;    medicarpin;    sativan;    betulinic acid;    Sesbania grandiflora;    antituberculosis activity;    Mycobacterium tuberculosis;   

DOI  :  10.3390/ph5080882

来源: mdpi

【 摘 要 】

Three isoflavanoids, isovestitol (1), medicarpin (2), and sativan (3), along with another known compound, betulinic acid (4), were isolated from the root of Sesbania grandiflora. The structures of the isolated compounds were characterised by means of spectroscopic techniques (UV, IR, MS, ¹H- and ¹³C-NMR, DEPT, COSY, HMQC, HMBC, and MS analysis). All the tested compounds 1–4 exhibited antituberculosis activity against Mycobacterium tuberculosis H37Rv, with MIC values of 50 µg/mL for compounds 1–3, and 100 µg/mL for compound 4, whereas, the methanol extract exhibited antituberculosis activity of 625 µg/mL. This is the first report on the occurrence of isoflavonoids in this plant and their antituberculosis activity.

【 授权许可】

CC BY   
© 2012 by the authors; licensee MDPI, Basel, Switzerland.