Sumoylation and the DNA Damage Response

Biomolecules

Catherine A. Cremona¹  Prabha Sarangi¹ 

[1] Molecular Biology Program, Memorial Sloan-Kettering Cancer Center, New York, NY 10065, USA;

关键词: sumoylation;    DNA damage response;    genome integrity;   

DOI  :  10.3390/biom2030376

来源: mdpi

【 摘 要 】

The cellular response to DNA damage involves multiple pathways that work together to promote survival in the face of increased genotoxic lesions. Proteins in these pathways are often posttranslationally modified, either by small groups such as phosphate, or by protein modifiers such as ubiquitin or SUMO. The recent discovery of many more SUMO substrates that are modified at higher levels in damage conditions adds weight to the accumulated evidence suggesting that sumoylation plays an important functional role in the DNA damage response. Here we discuss the significance of DNA damage-induced sumoylation, the effects of sumoylation on repair proteins, sumoylation dynamics, and crosstalk with other posttranslational modifications in the DNA damage response.

【 授权许可】

CC BY   
© 2012 by the authors; licensee MDPI, Basel, Switzerland.