The Dual Role of Inflammation in Colon Carcinogenesis

International Journal of Molecular Sciences

Giovanni Monteleone¹  Francesco Pallone¹ 

[1] Department of Systems Medicine, University of Rome “Tor Vergata”, Via Montpellier 1, Rome 00133, Italy;

关键词: colitis-associated colon cancer;    IBD;    ulcerative colitis;    AOM + DSS;    tumor immunosurveillance;    T cells;    inflammation;    IL-21;    IL-6;    IL-17;   

DOI  :  10.3390/ijms130911071

来源: mdpi

【 摘 要 】

Chronic inflammation characterizing patients with inflammatory bowel disease (IBD) represents a major risk factor for the development of colorectal cancer. Mechanisms underlying this neoplastic transformation are not fully understood though studies in experimental models of colon carcinogenesis suggest that inflammatory cell-derived cytokines either directly or indirectly stimulate the uncontrolled growth of cancer cells. Nevertheless, under specific inflammatory conditions, immune cells can boost an anti-tumor immune response with the down-stream effect of eliminating dysplastic and cancerous cells. This review outlines the beneficial and detrimental role of inflammation in colon carcinogenesis.

【 授权许可】

CC BY   
© 2012 by the authors; licensee Molecular Diversity Preservation International, Basel, Switzerland.