The Dual Action of Epigallocatechin Gallate (EGCG), the Main Constituent of Green Tea, against the Deleterious Effects of Visible Light and Singlet Oxygen-Generating Conditions as Seen in Yeast Cells

Molecules

Radu Mitrica¹  Ioana Dumitru¹  Lavinia L. Ruta¹  Augustin M. Ofiteru¹ 

[1] ¹Postgraduate Department of Biochemistry, University of Medicine & Pharmacy “Carol Davila”, Sos. Fundeni 258, Bucharest, Romania ²Department of Organic Chemistry, Biochemistry and Catalysis, Faculty of Chemistry, University of Bucharest, Sos. Panduri 90-92, Bucharest, Romania ^†These authors contributed equally to this work.

关键词: green tea;    epigallocatechin gallate;    Saccharomyces cerevisiae;    visible light;    singlet oxygen;    UV-A;   

DOI  :  10.3390/molecules170910355

来源: mdpi

【 摘 要 】

Green tea extracts (GTEs) as well as their main component, the polyphenol epigallocatechin gallate (EGCG), are known for their versatile antioxidant, antimicrobial, antitumoral or anti-inflammatory effects. In spite of the huge beneficial action, there is increasing evidence that under certain conditions green tea and its components can be detrimental to living organisms. Using Saccharomyces cerevisiae strains with various defects in the response to oxidative stress, we found that GTEs or EGCG act in synergy with visible light, exhibiting either deleterious or protective effects depending on the solvent employed. Similar synergistic effects could be observed under singlet oxygen-generating conditions, such as light exposure in the presence of photosensitizers or UV-A irradiation, therefore solvent variance may represent a powerful tool to modulate the preparation of green tea extracts, depending on the intended target.

【 授权许可】

CC BY   
This is an open access article distributed under the Creative Commons Attribution License (CC BY) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.