Vectors for Inhaled Gene Therapy in Lung Cancer. Application for Nano Oncology and Safety of Bio Nanotechnology

International Journal of Molecular Sciences

Paul Zarogouldis⁴  Nikos K. Karamanos¹  Konstantinos Porpodis⁴  Kalliopi Domvri⁴  Haidong Huang²  Wolfgang Hohenforst-Schimdt⁵  Eugene P. Goldberg³ 

[1] Laboratory of Biochemistry, University of Patras, Patras 25200, Greece; E-Mail:;Department of Respiratory diseases, Changhai hospital, Second Military Medical University, Shanghai 200433, China; E-Mail:;Biomaterials Science & Engineering, Department of Materials Science & Engineering, University of Florida, FL 32611, USA; E-Mail:;Pulmonary Department-Oncology Unit, “G. Papanikolaou” General Hospital, Aristotle University of Thessaloniki, Thessaloniki 57010, Greece; E-Mails:;II Medical Clinic, Hospital of Coburg, University of Wurzburg, Coburg 96450, Germany; E-Mail:

关键词: lung cancer;    inhaled gene therapy;    non-viral vectors;    nanocomplexes;    nanobiotechnology;   

DOI  :  10.3390/ijms130910828

来源: mdpi

【 摘 要 】

Novel aerosol therapeutic modalities have been investigated for lung cancer. Inhaled gene therapy has presented safety and effectiveness previously in cystic fibrosis. However, safety concerns have been raised regarding the safety of non-viral vectors for inhaled gene therapy in lung cancer, and therefore small steps have been made towards this multifunctional treatment modality. During the last decade, numerous new nanocomplexes have been created and investigated as a safe gene delivery nano-vehicle. These formulations are multifunctional; they can be used as either local therapy or carrier for an effective inhaled gene therapy for lung cancer. Herein, we present current and future perspectives of nanocomplexes for inhaled gene therapy treatment in lung cancer.

【 授权许可】

CC BY   
© 2012 by the authors; licensee Molecular Diversity Preservation International, Basel, Switzerland.