Effects of Glycerol and Creatine Hyperhydration on Doping-Relevant Blood Parameters

Nutrients

Thelma P. Polyviou³  Chris Easton²  Lukas Beis³  Dalia Malkova⁵  Pantazis Takas³  Catherine Hambly⁴  John R. Speakman⁴  Karsten Koehler¹ 

[1] Institute of Biochemistry, German Research Center of Elite Sport, German Sport University Cologne, Cologne 50933, Germany;Faculty of Science, Engineering and Computing, Kingston University, Kingston upon Thames, Surrey KT1 2EE, UK;Institute of Cardiovascular & Medical Sciences, College of Medicine, Veterinary and Life Sciences, University of Glasgow, Glasgow, G12 8QQ, UK;Institute of Biological and Environmental Sciences, University of Aberdeen, Tillydrone Ave, Aberdeen AB24 2TZ, UK;Medical School, College of Medicine, Veterinary and Life Sciences, University of Glasgow, Glasgow G12 8QQ, UK;

关键词: masking agent;    glycerol;    creatine;    hyperhydration;    doping markers;   

DOI  :  10.3390/nu4091171

来源: mdpi

【 摘 要 】

Glycerol is prohibited as an ergogenic aid by the World Anti-Doping Agency (WADA) due to the potential for its plasma expansion properties to have masking effects. However, the scientific basis of the inclusion of Gly as a “masking agent” remains inconclusive. The purpose of this study was to determine the effects of a hyperhydrating supplement containing Gly on doping-relevant blood parameters. Nine trained males ingested a hyperhydrating mixture twice per day for 7 days containing 1.0 g·kg⁻¹ body mass (BM) of Gly, 10.0 g of creatine and 75.0 g of glucose. Blood samples were collected and total hemoglobin (Hb) mass determined using the optimized carbon monoxide (CO) rebreathing method pre- and post-supplementation. BM and total body water (TBW) increased significantly following supplementation by 1.1 ± 1.2 and 1.0 ± 1.2 L (BM, P < 0.01; TBW, P <0.01), respectively. This hyperhydration did not significantly alter plasma volume or any of the doping-relevant blood parameters (e.g., hematocrit, Hb, reticulocytes and total Hb-mass) even when Gly was clearly detectable in urine samples. In conclusion, this study shows that supplementation with hyperhydrating solution containing Gly for 7 days does not significantly alter doping-relevant blood parameters.

【 授权许可】

CC BY   
© 2012 by the authors; licensee MDPI, Basel, Switzerland.