Promising Therapeutics with Natural Bioactive Compounds for Improving Learning and Memory — A Review of Randomized Trials

Molecules

Hemant Kumar¹  Sandeep Vasant More¹  Sang-Don Han¹  Jin-Yong Choi¹ 

[1] ¹Department of Biotechnology, Konkuk University, Chungju 380-701, Korea ²Department of Neurology, School of Medicine, Konkuk University, Chungju 380-704, Korea

关键词: learning and memory;    cognition;    clinical trials;    herbal medicines;    panax gingseng;    EGb 761;    BT-11;    GK501;    asarone;    tofu;   

DOI  :  10.3390/molecules170910503

来源: mdpi

【 摘 要 】

Cognitive disorders can be associated with brain trauma, neurodegenerative disease or as a part of physiological aging. Aging in humans is generally associated with deterioration of cognitive performance and, in particular, learning and memory. Different therapeutic approaches are available to treat cognitive impairment during physiological aging and neurodegenerative or psychiatric disorders. Traditional herbal medicine and numerous plants, either directly as supplements or indirectly in the form of food, improve brain functions including memory and attention. More than a hundred herbal medicinal plants have been traditionally used for learning and memory improvement, but only a few have been tested in randomized clinical trials. Here, we will enumerate those medicinal plants that show positive effects on various cognitive functions in learning and memory clinical trials. Moreover, besides natural products that show promising effects in clinical trials, we briefly discuss medicinal plants that have promising experimental data or initial clinical data and might have potential to reach a clinical trial in the near future.

【 授权许可】

CC BY   
This is an open access article distributed under the Creative Commons Attribution License (CC BY) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.