Hydrogel-Based Platforms for the Regeneration of Osteochondral Tissue and Intervertebral Disc

Polymers

Vincenzo Guarino¹  Antonio Gloria²  Maria Grazia Raucci² 

[1] Institute of Composite and Biomedical Materials, National Research Council of Italy, P.le Tecchio 80, Naples 80125, Italy;

关键词: hydrogels;    osteochondral tissue;    disc nucleus;    scaffolds;    tissue regeneration;   

DOI  :  10.3390/polym4031590

来源: mdpi

【 摘 要 】

Hydrogels currently represent a powerful solution to promote the regeneration of soft and hard tissues. Primarily, they assure efficient bio-molecular interactions with cells, also regulating their basic functions, guiding the spatially and temporally complex multi-cellular processes of tissue formation, and ultimately facilitating the restoration of structure and function of damaged or dysfunctional tissues. In order to overcome basic drawbacks of traditional synthesized hydrogels, many recent strategies have been implemented to realize multi-component hydrogels based on natural and/or synthetic materials with tailored chemistries and different degradation kinetics. Here, a critical review of main strategies has been proposed based on the use of hydrogels-based devices for the regeneration of complex tissues, i.e., osteo-chondral tissues and intervertebral disc.

【 授权许可】

CC BY   
© 2012 by the authors; licensee MDPI, Basel, Switzerland.