Meroterpenes from Endophytic Fungus A1 of Mangrove Plant Scyphiphora hydrophyllacea

Marine Drugs

Wen-Li Mei³  Bo Zheng³  You-Xing Zhao³  Hui-Ming Zhong¹  Xun-Li Wu Chen³  Yan-Bo Zeng³  Wen-Hua Dong³  Jiu-Li Huang³  Peter Proksch² 

[1] College of Chemistry and Molecular Engineering, Qingdao University of Science and Technology, Qingdao 266042, China;Institute of Pharmaceutical Biology and Biotechnology, Heinrich-Heine-Universitaet Duesseldorf, Duesseldorf 40225, Germany;Key Laboratory of Biology and Genetic Resources of Tropical Crops, Ministry of Agriculture, Institute of Tropical Bioscience and Biotechnology, Chinese Academy of Tropical Agriculture Sciences, Haikou 571101, China;

关键词: marine endophyte;    Scyphiphora hydrophyllacea;    meroterpenes;    Guignardia sp.;    MRSA;    Staphylococcus aureus;   

DOI  :  10.3390/md10091993

来源: mdpi

【 摘 要 】

Four new meroterpenes, guignardones F–I (1–4), together with two known compounds guignardones A (5) and B (6) were isolated from the endophytic fungus A1 of the mangrove plant Scyphiphora hydrophyllacea. Their structures and relative configurations were elucidated by spectroscopic data and single-crystal X-ray crystallography. A possible biogenetic pathway of compounds 1–6 was also proposed. All compounds were evaluated for inhibitory activity against methicillin-resistant Staphylococcus aureus (MRSA) and Staphylococcus aureus.

【 授权许可】

CC BY   
© 2012 by the authors; licensee MDPI, Basel, Switzerland.