Protective Effect of Anthocyanin from Lonicera Caerulea var. Edulis on Radiation-Induced Damage in Mice

International Journal of Molecular Sciences

Haitian Zhao¹  Zhenyu Wang¹  Fengming Ma¹  Xin Yang¹  Cuilin Cheng¹ 

[1]School of Food Science and Engineering, Harbin Institute of Technology, Harbin 150090, China

[2] E-Mails:

关键词: anthocyanin;    Lonicera caerulea var. edulis;    ⁶⁰Coγ radiation;    mice;    radioprotection;   

DOI  :  10.3390/ijms130911773

来源: mdpi

【 摘 要 】

The radioprotective effect of anthocyanin extracted from Lonicera caerulea var. edulis (ALC), was studied in ICR mice. Different doses of ALC were intragastrically administered to mice once a day, prior to radiation. After two weeks, the mice received a one-time 5 Gy whole body ⁶⁰Coγ radiation. The spleen index, thymus index, activities of superoxide dismutase (SOD) and glutathione peroxidase (GSH-Px), malondialdehyde (MDA) content, and glutathione (GSH) content in liver tissue were measured. Compared with the radiation control group, the levels of MDA in all ALC treated groups decreased significantly (p < 0.05). Moreover, the GSH content, activities of SOD and GSH-Px in liver tissue were enhanced significantly (p < 0.05) in all ALC groups. These results demonstrate that ALC may be a potential radioprotector, and a further study of the molecular mechanism is needed for further application.

【 授权许可】

CC BY   
© 2012 by the authors; licensee Molecular Diversity Preservation International, Basel, Switzerland.