International Journal of Molecular Sciences | |
Common Fragile Sites: Genomic Hotspots of DNA Damage and Carcinogenesis | |
Ke Ma2  Li Qiu2  Kristin Mrasek1  Jun Zhang2  Thomas Liehr1  Luciana Gonlves Quintana1  | |
[1] Institute of Human Genetics, Jena University Hospital, Friedrich Schiller University, D-07743 Jena, Germany; E-Mails:;Department of Biochemistry and Molecular Biology, Tianjin Medical University Cancer Institute and Hospital, Tianjin 300060, China; E-Mails: | |
关键词:
replication;
instability;
CFS;
cancer;
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DOI : 10.3390/ijms130911974 | |
来源: mdpi | |
【 摘 要 】
Genomic instability, a hallmark of cancer, occurs preferentially at specific genomic regions known as common fragile sites (CFSs). CFSs are evolutionarily conserved and late replicating regions with AT-rich sequences, and CFS instability is correlated with cancer. In the last decade, much progress has been made toward understanding the mechanisms of chromosomal instability at CFSs. However, despite tremendous efforts, identifying a cancer-associated CFS gene (CACG) remains a challenge and little is known about the function of CACGs at most CFS loci. Recent studies of
【 授权许可】
CC BY
© 2012 by the authors; licensee Molecular Diversity Preservation International, Basel, Switzerland.
【 预 览 】
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RO202003190041798ZK.pdf | 425KB | download |