Estrogen Signaling in Lung Cancer: An Opportunity for Novel Therapy

Cancers

Christina S. Baik¹ 

[1] Division of Medical Oncology, Department of Medicine, University of Washington, Seattle, WA 98109, USA; E-Mail:

关键词: lung cancer;    estrogen;    progesterone;    aromatase;    hormone receptors;   

DOI  :  10.3390/cancers4040969

来源: mdpi

【 摘 要 】

Lung cancer is the leading cause of cancer death in U.S. and represents a major public health burden. Epidemiologic data have suggested that lung cancer in women may possess different biological characteristics compared to men, as evidenced by a higher proportion of never-smokers among women with lung cancer. Emerging data indicate that female hormones such as estrogen and progesterone play a significant role in lung carcinogenesis. It has been reported that estrogen and progesterone receptors are expressed in lung cancer cell lines as well as in patient-derived tumors. Hormone related risk factors such as hormone replacement therapy have been implicated in lung carcinogenesis and several preclinical studies show activity of anti-estrogen therapy in lung cancer. In this review, we summarize the emerging evidence for the role of reproductive hormones in lung cancer and implications for lung cancer therapy.

【 授权许可】

CC BY   
© 2012 by the authors; licensee MDPI, Basel, Switzerland.