Benzopyranones from the Endophytic Fungus Hyalodendriella sp. Ponipodef12 and Their Bioactivities

Molecules

Xiangjie Meng¹  Ziling Mao¹  Jingfeng Lou¹  Liang Xu¹  Lingyun Zhong¹  Youliang Peng¹  Ligang Zhou¹ 

[1] ¹College of Agronomy and Biotechnology, China Agricultural University, Beijing 100193, China ²College of Science, China Agricultural University, Beijing 100193, China

关键词: poplar hybrid ‘Neva’ endophytic fungus;    Hyalodendriella sp. Ponipodef12;    benzopyranones;    palmariol B;    4-hydroxymellein;    alternariol 9-methyl ether;    botrallin;    bioactivities;   

DOI  :  10.3390/molecules171011303

来源: mdpi

【 摘 要 】

The endophytic fungus Hyalodendriella sp. Ponipodef12 was isolated from the hybrid ‘Neva’ of Populus deltoides Marsh × P. nigra L. In this study, four benzopyranones were isolated from the ethyl acetate extract of Hyalodendriella sp. Ponipodef12, and identified as palmariol B (1), 4-hydroxymellein (2), alternariol 9-methyl ether (3), and botrallin (4) by means of physicochemical and spectroscopic analysis. All the compounds were evaluated for their antibacterial, antifungal, antinematodal and acetylcholinesterase inhibitory activities. 4-Hydroxymellein (2) exhibited stronger antibacterial activity than the other compounds. Palmariol B (1) showed stronger antimicrobial, antinematodal and acetylcholinesterase inhibitory activities than alternariol 9-methyl ether (3) which indicated that the chlorine substitution at position 2 may contribute to its bioactivity. The results indicate the potential of this endophytic fungus as a source of bioactive benzopyranones.

【 授权许可】

CC BY   
This is an open access article distributed under the Creative Commons Attribution License (CC BY) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.