Silica Gel-Mediated Organic Reactions under Organic Solvent-Free Conditions

Molecules

Satoaki Onitsuka¹  Yong Zhi Jin¹  Ajam C. Shaikh¹  Hiroshi Furuno¹ 

[1] Institute for Materials Chemistry and Engineering (IMCE), Kyushu University, Hakozaki, Higashi-ku, Fukuoka 812-8581, Japan

关键词: aromatic nitration;    green synthetic process;    heterogeneous reaction;    Morita-Baylis-Hillman reaction;    one-pot Wittig-type olefination;    solid reaction medium;   

DOI  :  10.3390/molecules171011469

来源: mdpi

【 摘 要 】

Silica gel was found to be an excellent medium for some useful organic transformations under organic solvent-free conditions, such as (1) the Friedel-Crafts-type nitration of arenes using commercial aqueous 69% nitric acid alone at room temperature, (2) one-pot Wittig-type olefination of aldehydes with activated organic halides in the presence of tributyl- or triphenylphosphine and Hunig’s base, and (3) the Morita-Baylis-Hillman reaction of aldehydes with methyl acrylate. After the reactions, the desired products were easily obtained in good to excellent yields through simple manipulation.

【 授权许可】

CC BY   
This is an open access article distributed under the Creative Commons Attribution License (CC BY) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.