MicroRNAs as Diagnostic Biomarkers in Gastric Cancer

International Journal of Molecular Sciences

Ying Yin¹  Jun Li¹  Shujie Chen¹  Tianhua Zhou¹ 

[1] Institute of Clinical Research of Gastroenterology, Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University, 3 East Qingchun Road, Hangzhou 310016, China;

关键词: microRNAs;    gastric cancer;    biomarkers;    diagnosis;   

DOI  :  10.3390/ijms131012544

来源: mdpi

【 摘 要 】

Considering the high mortality rates and the unfavorable prognosis of gastric cancer (GC) as well as the lack of a clinical predictive marker, which is sufficiently sensitive to GC, it is of great significance to investigate new sensitive and specific markers for GC diagnosis. MicroRNAs (miRNAs) could be a practical form of potential biomarkers in the diagnosis of human disease, and they are confirmed to be closely associated with GC. In this review, we discuss the recent research results that indicate the feasibility and clinical applications of miRNAs in GC. Although several challenges remain to be addressed, miRNAs have the potential to be applied in the diagnosis of GC.

【 授权许可】

CC BY   
© 2012 by the authors; licensee Molecular Diversity Preservation International, Basel, Switzerland.