Forty-Five Years of Marburg Virus Research

Viruses

Kristina Brauburger¹  Adam J. Hume¹  Elke Mühlberger¹ 

关键词: Marburg virus;    filoviruses;    epidemiology;    ecology;    clinical manifestations;    virus structure;    replication cycle;    pathogenesis;    animal models;    vaccine development;   

DOI  :  10.3390/v4101878

来源: mdpi

【 摘 要 】

In 1967, the first reported filovirus hemorrhagic fever outbreak took place in Germany and the former Yugoslavia. The causative agent that was identified during this outbreak, Marburg virus, is one of the most deadly human pathogens. This article provides a comprehensive overview of our current knowledge about Marburg virus disease ranging from ecology to pathogenesis and molecular biology.

【 授权许可】

CC BY   
© 2012 by the authors; licensee MDPI, Basel, Switzerland.