Preparation and Physicochemical Properties of Vinblastine Microparticles by Supercritical Antisolvent Process

International Journal of Molecular Sciences

Xiaonan Zhang²  Xiuhua Zhao²  Yuangang Zu¹  Xiaoqiang Chen²  Qi Lu²  Yuliang Ma² 

[1] State Engineering Laboratory for Bio-Resource Eco-Utilization, Northeast Forestry University, 150040 Harbin, China;

关键词: vinblastine;    supercritical antisolvent;    micronization;    physicochemical property;    Catharanthus roseus;   

DOI  :  10.3390/ijms131012598

来源: mdpi

【 摘 要 】

The objective of the study was to prepare vinblastine microparticles by supercritical antisolvent process using N-methyl-2-pyrrolidone as solvent and carbon dioxide as antisolvent and evaluate its physicochemical properties. The effects of four process variables, pressure, temperature, drug concentration and drug solution flow rate, on drug particle formation during the supercritical antisolvent process, were investigated. Particles with a mean particle size of 121 ± 5.3 nm were obtained under the optimized process conditions (precipitation temperature 60 °C, precipitation pressure 25 MPa, vinblastine concentration 2.50 mg/mL and vinblastine solution flow rate 6.7 mL/min). The vinblastine was characterized by scanning electron microscopy, X-ray diffraction, Fourier-transform infrared spectroscopy, mass spectrometry and dissolution test. It was concluded that physicochemical properties of crystalline vinblastine could be improved by physical modification, such as particle size reduction and generation of amorphous state using the supercritical antisolvent process. Furthermore, the supercritical antisolvent process was a powerful methodology for improving the physicochemical properties of vinblastine.

【 授权许可】

CC BY   
© 2012 by the authors; licensee Molecular Diversity Preservation International, Basel, Switzerland.