The Inhibitor of Apoptosis (IAPs) in Adaptive Response to Cellular Stress

Cells

Arthur Marivin¹  Jean Berthelet¹  Stéphanie Plenchette² 

[1] Institut National de la Santé et de la Recherche Médicale (Inserm), UMR866, Dijon F-21079, France;Institut Fédératif de Recherche (IFR), Université de Bourgogne, 100, Dijon F-21079, France;

关键词: IAPs;    apoptosis;    caspases;    NF-κB;    TNFR;    UPR;    DNA damage response;    cancer;    neurodegenerative disease;   

DOI  :  10.3390/cells1040711

来源: mdpi

【 摘 要 】

Cells are constantly exposed to endogenous and exogenous cellular injuries. They cope with stressful stimuli by adapting their metabolism and activating various “guardian molecules.” These pro-survival factors protect essential cell constituents, prevent cell death, and possibly repair cellular damages. The Inhibitor of Apoptosis (IAPs) proteins display both anti-apoptotic and pro-survival properties and their expression can be induced by a variety of cellular stress such as hypoxia, endoplasmic reticular stress and DNA damage. Thus, IAPs can confer tolerance to cellular stress. This review presents the anti-apoptotic and survival functions of IAPs and their role in the adaptive response to cellular stress. The involvement of IAPs in human physiology and diseases in connection with a breakdown of cellular homeostasis will be discussed.

【 授权许可】

CC BY   
© 2012 by the authors; licensee MDPI, Basel, Switzerland.