Viruses | |
Hepatitis C Virus and Cellular Stress Response: Implications to Molecular Pathogenesis of Liver Diseases | |
Po-Yuan Ke1  | |
[1] Department of Biochemistry and Molecular Biology, College of Medicine, Chang Gung University, Taoyuan 33371, Taiwan, Republic of China; | |
关键词: HCV; host factor; cellular response; autophagy; ER stress; unfolded protein response; apoptosis; DNA damage; cell cycle arrest; liver diseases; | |
DOI : 10.3390/v4102251 | |
来源: mdpi | |
【 摘 要 】
Infection with hepatitis C virus (HCV) is a leading risk factor for chronic liver disease progression, including steatosis, cirrhosis, and hepatocellular carcinoma. With approximately 3% of the human population infected worldwide, HCV infection remains a global public health challenge. The efficacy of current therapy is still limited in many patients infected with HCV, thus a greater understanding of pathogenesis in HCV infection is desperately needed. Emerging lines of evidence indicate that HCV triggers a wide range of cellular stress responses, including cell cycle arrest, apoptosis,
【 授权许可】
CC BY
© 2012 by the authors; licensee MDPI, Basel, Switzerland.
【 预 览 】
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RO202003190041282ZK.pdf | 2052KB | download |