Effects of Oral Administration of Fucoidan Extracted from Cladosiphon okamuranus on Tumor Growth and Survival Time in a Tumor-Bearing Mouse Model

Marine Drugs

Kazuo Azuma³  Toshitsugu Ishihara³  Hiroyuki Nakamoto³  Takao Amaha³  Tomohiro Osaki³  Takeshi Tsuka³  Tomohiro Imagawa³  Saburo Minami³  Osamu Takashima²  Shinsuke Ifuku⁴  Minoru Morimoto⁴  Hiroyuki Saimoto⁴  Hitoshi Kawamoto¹ 

[1] Marine Products Kimura Co., LTD., 3307 Watari-cho Sakaiminato-shi, Tottori 684-0072, Japan;Scientific Crime Laboratory, Tottori Prefectural Police H. Q., 2-12 Chiyomi, Tottori 680-0911, Japan;Department of Veterinary Clinical Medicine, School of Veterinary Medicine, Tottori University, 4-101 Koyama-minami, Tottori-shi, Tottori 680-8553, Japan;The Graduate School of Engineering, Tottori University, 4-101 Koyama-minami, Tottori 680-8552, Japan;

关键词: fucoidan;    Cladosiphon okamuranu;    anti-tumor activities;    colon-26;    mice;    functional food;   

DOI  :  10.3390/md10102337

来源: mdpi

【 摘 要 】

We evaluated the anti-tumor activities of the oral administration of fucoidan extracted from Cladosiphon okamuranus using a tumor (colon 26)-bearing mouse model. The materials used included low-molecular-weight fucoidan (LMWF: 6.5–40 kDa), intermediate-molecular-weight fucoidan (IMWF: 110–138 kDa) and high-molecular-weight fucoidan (HMWF: 300–330 kDa). The IMWF group showed significantly suppressed tumor growth. The LMWF and HMWF groups showed significantly increased survival times compared with that observed in the control group (mice fed a fucoidan-free diet). The median survival times in the control, LMWF, IMWF and HMWF groups were 23, 46, 40 and 43 days, respectively. It was also found that oral administration of fucoidan increased the population of natural killer cells in the spleen. Furthermore, from the results of the experiment using Myd-88 knockout mice, it was found that these effects are related to gut immunity. These results suggest that fucoidan is a candidate anti-tumor functional food.

【 授权许可】

CC BY   
© 2012 by the authors; licensee MDPI, Basel, Switzerland.