trans-Resveratrol in Nutraceuticals: Issues in Retail Quality and Effectiveness

Molecules

Damiano Rossi²  Alessandra Guerrini²  Renato Bruni³  Eleonora Brognara¹  Monica Borgatti¹  Roberto Gambari¹  Silvia Maietti² 

[1] Dipartimento Scienze della Vita e Biotecnologie, Sezione Biochimica e Biologia Molecolare, Università di Ferrara, Via Fossato di Mortara 74, 44121 Ferrara, Italy;Dipartimento Scienze della Vita e Biotecnologie-SVEB, UR7 Terra&Acqua Tech-Università di Ferrara, Corso Ercole I d’Este 32, 44121 Ferrara, Italy;Dipartimento di Scienze degli Alimenti, Università di Parma, Viale G.P. Usberti 11A, I-43124 Parma, Italy

关键词: resveratrol;    food supplements;    dietary supplements;    nutraceuticals;    quality control;   

DOI  :  10.3390/molecules171012393

来源: mdpi

【 摘 要 】

Fourteen brands of resveratrol-containing nutraceuticals were evaluated in order to verify their actual resveratrol content and to control if their health-promoting properties are related to manufacturing quality. Products included pure resveratrol capsules or multi-ingredient formulations with standardized amounts of resveratrol and other phytochemicals. Samples were analyzed for total trans-resveratrol, flavonoids, procyanidin, polyphenol content and the results were compared with the content declared on-label. Only five out of 14 brands had near label values, compliant with Good Manufacturing Practices (GMP) requirements (95–105% content of active constituent), four products were slightly out of this range (83–111%) and three were in the 8–64% range. Two samples were below the limit of detection. The greater the difference between actual and labeled resveratrol content, the lower was the antioxidant and antiproliferative activity strength. Dietary supplements containing pure trans-resveratrol exhibited a greater induction of differentiation towards human leukemic K562 cells when compared to multicomponent products. Great differences currently exist among resveratrol food supplements commercially available and GMP-grade quality should not be taken for granted. On the other side, dosages suggested by most “pure”, “high-dosage” supplements may allow a supplementation level adequate to obtain some of the purported health benefits.

【 授权许可】

CC BY   
© 2012 by the authors; licensee MDPI, Basel, Switzerland.