Lack of Association of Estrogen Receptor Alpha Gene Polymorphisms with Cardiorespiratory and Metabolic Variables in Young Women

International Journal of Molecular Sciences

Ana Cristina Rebelo³  Rozangela Verlengia⁴  Vandeni Kunz⁵  Nayara Tamburus¹  Alvaro Cerda²  Rosario Hirata²  Mario Hirata² 

[1] Federal University of São Carlos, Rodovia Washington Luís, km 235-SP-310, 13565-905, Sao Carlos, SP, Brazil; E-Mails:;Lab Applied Molecular Biology and Pharmacogenomics, Federal University of São Paulo, Av. Prof. Lineu Prestes, 58005508-900, Sao Paulo, SP, Brazil; E-Mails:;Department of Morphology, (Campus II), Federal University of Goiás, 74001-970, Goiânia, GO, Brazil;College of Health Sciences, Methodist University of Piracicaba, Rodovia Açucar, Km 151, 13400-911, Piracicaba, SP, Brazil; E-Mail:;Adventist University Center São Paulo, 13165-970, Engenheiro Coellho, SP, Brazil; E-Mail:

关键词: estrogen receptor-α gene polymorphisms;    heart rate variability;    aerobic capacity;    lipids;   

DOI  :  10.3390/ijms131013691

来源: mdpi

【 摘 要 】

This study examined the association of estrogen receptor alpha gene (ESR1) polymorphisms with cardiorespiratory and metabolic parameters in young women. In total, 354 healthy women were selected for cardiopulmonary exercise testing and short-term heart rate (HR) variability (HRV) evaluation. The HRV analysis was determined by the temporal indices rMSSD (square root of the mean squared differences of successive R–R intervals (RRi) divided by the number of RRi minus one), SDNN (root mean square of differences from mean RRi, divided by the number of RRi) and power spectrum components by low frequency (LF), high frequency (HF) and LF/HF ratio. Blood samples were obtained for serum lipids, estradiol and DNA extraction. ESR1 rs2234693 and rs9340799 polymorphisms were analyzed by PCR and fragment restriction analysis. HR and oxygen uptake (VO₂) values did not differ between the ESR1 polymorphisms with respect to autonomic modulation. We not find a relationship between ESR1 T–A, T–G, C–A and C–G haplotypes and cardiorespiratory and metabolic variables. Multiple linear regression analysis demonstrated that VO₂, total cholesterol and triglycerides influence HRV (p < 0.05). The results suggest that ESR1 variants have no effect on cardiorespiratory and metabolic variables, while HRV indices are influenced by aerobic capacity and lipids in healthy women.

【 授权许可】

CC BY   
© 2012 by the authors; licensee Molecular Diversity Preservation International, Basel, Switzerland.