The Baboon (Papio spp.) as a Model of Human Ebola Virus Infection

Viruses

Donna L. Perry¹  Laura Bollinger¹ 

[1]Integrated Research Facility, Division of Clinical Research, NIAID, NIH, Frederick, MD, USA

关键词: Filoviridae;    Filovirus;    Baboon;    Papio spp.;    Ebola virus;    Marburg virus;    BSL-4;   

DOI  :  10.3390/v4102400

来源: mdpi

【 摘 要 】

Baboons are susceptible to natural Ebola virus (EBOV) infection and share 96% genetic homology with humans. Despite these characteristics, baboons have rarely been utilized as experimental models of human EBOV infection to evaluate the efficacy of prophylactics and therapeutics in the United States. This review will summarize what is known about the pathogenesis of EBOV infection in baboons compared to EBOV infection in humans and other Old World nonhuman primates. In addition, we will discuss how closely the baboon model recapitulates human EBOV infection. We will also review some of the housing requirements and behavioral attributes of baboons compared to other Old World nonhuman primates. Due to the lack of data available on the pathogenesis of Marburg virus (MARV) infection in baboons, discussion of the pathogenesis of MARV infection in baboons will be limited.

【 授权许可】

CC BY   
© 2012 by the authors; licensee MDPI, Basel, Switzerland.