From Exit to Entry: Long-term Survival and Transmission of Salmonella

Pathogens

Landon L. Waldner¹  Keith D. MacKenzie¹  Wolfgang Köster,¹ 

[1] Vaccine and Infectious Disease Organization, University of Saskatchewan, Saskatoon, Saskatchewan, S7N 5E3, Canada.

关键词: Salmonella;    transmission;    persistence;    outbreak;    rdar morphotype;    tomato;    sprouts;    chocolate;    genomics;   

DOI  :  10.3390/pathogens1020128

来源: mdpi

【 摘 要 】

Salmonella spp. are a leading cause of human infectious disease worldwide and pose a serious health concern. While we have an improving understanding of pathogenesis and the host-pathogen interactions underlying the infection process, comparatively little is known about the survival of pathogenic Salmonella outside their hosts. This review focuses on three areas: (1) in vitro evidence that Salmonella spp. can survive for long periods of time under harsh conditions; (2) observations and conclusions about Salmonella persistence obtained from human outbreaks; and (3) new information revealed by genomic- and population-based studies of Salmonella and related enteric pathogens. We highlight the mechanisms of Salmonella persistence and transmission as an essential part of their lifecycle and a prerequisite for their evolutionary success as human pathogens.

【 授权许可】

CC BY   
© 2012 by the authors; licensee MDPI, Basel, Switzerland.