Development of a Taste-Masked Orodispersible Film Containing Dimenhydrinate

Pharmaceutics

Maren Preis¹  Miriam Pein¹ 

[1] id="af1-pharmaceutics-04-00551">Institute of Pharmaceutics and Biopharmaceutics, University of Düsseldorf; Universitätsstraße 1, 40225 Düsseldorf, Germa

关键词: Orodispersible film;    orally disintegrating dosage form;    taste-masking;    electronic taste sensing;    electronic tongues;    dimenhydrinate;    cyclodextrin;    maltodextrin;    solubility;    solvent casting;   

DOI  :  10.3390/pharmaceutics4040551

来源: mdpi

【 摘 要 】

Orodispersible dosage forms are promising new approaches for drug delivery. They enable an easy application, as there is no need to drink high amounts of liquids or swallow large solid dosage forms. The aim of the study was to develop an orodispersible film (ODF) as an alternative to tablets, syrups or suppositories for the treatment of vomiting and nausea, especially for the pediatric population. Formulations were investigated by X-ray diffraction, scanning electron and polarized light microscopy. Additionally, two commercially available electronic taste sensing systems were used to investigate the applied taste-masking strategies. Results obtained from X-ray-diffraction and polarized light microscopy showed no recrystallization of dimenhydrinate in the formulation when cyclodextrin or maltodextrin were used as solubilizing and complexing agent. All ODFs showed fast disintegration depending on the characterization method. In order to get taste information, the dimenhydrinate formulations were analytically compared to pure drug and drug-free formulations by electronic tongues. Results obtained from both systems are comparable and were used together for the first time. It was possible to develop an ODF of dimenhydrinate that is fast disintegrating even in small volumes of liquid. Furthermore, in vitro taste assessment by two electronic tongues revealed taste-masking effects by the excipients.

【 授权许可】

CC BY   
© 2012 by the authors; licensee MDPI, Basel, Switzerland.