MicroRNAs, Hepatitis C Virus, and HCV/HIV-1 Co-Infection: New Insights in Pathogenesis and Therapy

Viruses

Archana Gupta¹  Gokul Swaminathan¹  Julio Martin-Garcia¹ 

[1] Department of Microbiology and Immunology, Drexel University College of Medicine, 245 North 15th Street, Philadelphia, PA 19102, USA;

关键词: microRNA;    miR-122;    exosomes;    HCV;    hepatitis C virus;    hepatitis;    antiviral response;    HIV-1;    HIV-1/HCV co-infection;    antagomir;    therapeutics;   

DOI  :  10.3390/v4112485

来源: mdpi

【 摘 要 】

MicroRNAs (miRNAs) can exert a profound effect on Hepatitis C virus (HCV) replication. The interaction of HCV with the highly liver-enriched miRNA, miR-122 represents one such unique example of viruses having evolved mechanism(s) to usurp the host miRNA machinery to support viral life cycle. Furthermore, HCV infection can also trigger changes in the cellular miRNA profile, which may ultimately contribute to the outcome of viral infection. Accumulating knowledge on HCV-host miRNA interactions has ultimately influenced the design of therapeutic interventions against chronic HCV infection. The importance of microRNA modulation in Human Immunodeficiency Virus (HIV-1) replication has been reported, albeit only in the context of HIV-1 mono-infection. The development of HCV infection is dramatically influenced during co-infection with HIV-1. Here, we review the current knowledge on miRNAs in HCV mono-infection. In addition, we discuss the potential role of some miRNAs, identified from the analyses of public data, in HCV/HIV-1 co-infection.

【 授权许可】

CC BY   
© 2012 by the authors; licensee MDPI, Basel, Switzerland.