Vitamin D Interactions with Soy Isoflavones on Bone after Menopause: A Review

Nutrients

Clara Y. Park¹ 

[1] Department of Nutrition Science, Purdue University, 700 W State St, West Lafayette, IN 47907, USA;

关键词: vitamin D;    phytoestrogen;    soy isoflavones;    bone;    postmenopause;   

DOI  :  10.3390/nu4111610

来源: mdpi

【 摘 要 】

Vitamin D is known to increase Ca absorption in adults. However, the threshold vitamin D status to benefit Ca absorption is lower than the target vitamin D status for higher bone mineral density and lower fracture risk, pointing to another pathway for vitamin D to benefit bone. One possibility is by affecting osteoblast and osteoclasts directly. Vitamin D-related bone metabolism may also be affected by soy isoflavones, which selectively bind to the estrogen receptor β and may reduce bone loss in postmenopausal women. We discuss a possible synergistic effect of soy isoflavones and vitamin D on bone by affecting osteoblast and osteoclast formation and activity in postmenopausal women.

【 授权许可】

CC BY   
© 2012 by the authors; licensee MDPI, Basel, Switzerland.