Allylation of Functionalized Aldehydes by Potassium Allyltrifluoroborate Catalyzed by 18-Crown-6 in Aqueous Media

Molecules

Fernanda C. G. Barbosa¹  Juliano C. R. Freitas¹  Caio F. Melo¹  Paulo H. Menezes¹ 

[1] id="af1-molecules-17-14099">Departamento de Química Fundamental, Universidade Federal de Pernambuco, Av. Jornalista Aníbal Fernandes, s/n - Cidade Universitária, Recife – PE, 50740-560, Braz

关键词: potassium allyltrifluoroborate;    allylation;    18-crown-6;   

DOI  :  10.3390/molecules171214099

来源: mdpi

【 摘 要 】

An efficient method for the allylation of aldehydes containing a broad range of functional groups using potassium allyltrifluoroborate is described. The reaction utilizes a catalytic amount of 18-C-6 in biphasic media under open atmosphere and room temperature to provide the corresponding homoallylic alcohols in high yields and without the necessity of any subsequent purification.

【 授权许可】

CC BY   
© 2012 by the authors; licensee MDPI, Basel, Switzerland.