Ultrasound-Promoted Greener Synthesis of Novel Trifurcate 3-Substituted-chroman-2,4-dione Derivatives and Their Drug-Likeness Evaluation

Molecules

Chengyuan Liang¹  Hailong Jiang¹  Zhiguang Zhou¹  Dong Lei¹  Yu Xue¹ 

[1] School of Pharmacy, China Pharmaceutical University, Nanjing 210009, Jiangsu, China;

关键词: chroman-2;    4-diones;    multicomponent reactions (MCRs);    ultrasonic irradiation;    green chemistry;    coumarin;    edaravone;   

DOI  :  10.3390/molecules171214146

来源: mdpi

【 摘 要 】

An efficient and convenient approach for one-pot synthesis of 3-substituted chroman-2,4-diones via a three-component reaction of aromatic aldehydes, 4-hydroxy- coumarins and diverse pyrazolone derivatives was described. The combinatorial synthesis for this methodology was achieved by applying ultrasound irradiation in the absence of activator while making use of water as green solvent. Additionally, novel chroman-2,4-dione derivatives attached to an edaravone moiety represent an exploitable source of brand new anticancer agents. In comparison with conventional methods, experimental simplicity, good functional group tolerance, excellent yields, short routine, and atom efficiency are prominent features of this sonocatalyzed procedure.

【 授权许可】

CC BY   
© 2012 by the authors; licensee MDPI, Basel, Switzerland.