International Journal of Molecular Sciences | |
Experimental and Therapeutic Opportunities for Stem Cells in Multiple Sclerosis | |
Rickie Patani1  | |
[1] Anne McLaren Laboratory for Regenerative Medicine, Stem Cell Institute, University of Cambridge, Forvie Site, Robinson Way, Cambridge CB2 0SZ, UK; E-Mail: | |
关键词: multiple sclerosis (MS); embryonic stem cells (ESCs); pluripotent stem cells (PSCs); induced pluripotent stem cells (iPSCs); neurodegenerative disease; | |
DOI : 10.3390/ijms131114470 | |
来源: mdpi | |
【 摘 要 】
Multiple Sclerosis (MS) is an inflammatory demyelinating neurodegenerative disorder of the brain and spinal cord that causes significant disability in young adults. Although the precise aetiopathogenesis of MS remains unresolved, its pathological hallmarks include inflammation, demyelination, axonal injury (acute and chronic), astrogliosis and variable remyelination. Despite major recent advances in therapeutics for the early stage of the disease there are currently no disease modifying treatments for the progressive stage of disease, whose pathological substrate is axonal degeneration. This represents the great and unmet clinical need in MS. Against this background, human stem cells offer promise both to improve understanding of disease mechanism(s) through
【 授权许可】
CC BY
© 2012 by the authors; licensee Molecular Diversity Preservation International, Basel, Switzerland.
【 预 览 】
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RO202003190040495ZK.pdf | 375KB | download |