Beckmann Rearrangement of Ketoximes Induced by Phenyl Dichlorophosphate at Ambient Temperature

Molecules

Chun-Wei Kuo¹  Min-Tsang Hsieh¹  Shijay Gao¹  Yi-Ming Shao¹  Ching-Fa Yao¹ 

[1] ¹Institute of Biotechnology and Pharmaceutical Research, National Health Research Institutes, Miaoli County 35053, Taiwan ²Department of Chemistry, National Taiwan Normal University, Taipei 116, Taiwan ³Chinese Medicinal Research and Development Center, China Medical University Hospital, 2 Yude Road, Taichung 40447, Taiwan

关键词: Beckmann rearrangement;    phenyl dichlorophosphate;    ketoximes;    ambient temperature;   

DOI  :  10.3390/molecules171113662

来源: mdpi

【 摘 要 】

Upon treatment with phenyl dichlorophosphate (PhOP=OCl₂) in acetonitrile at ambient temperature, a variety of ketoximes underwent a Beckmann rearrangement in an effective manner to afford the corresponding amides in moderate to high yields.

【 授权许可】

CC BY   
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