Cell-Sized Liposomes and Droplets: Real-World Modeling of Living Cells

Materials

Tsutomu Hamada¹ 

[1] School of Materials Science,Japan Advanced Institute of Science and Technology, 1-1, Asahidai, Nomi, Ishikawa 923-1292, Japan

关键词: liposome;    droplet;    cell-sized confinement;    lipid membrane;    DNA;    compartmentalization;    nanoparticle;   

DOI  :  10.3390/ma5112292

来源: mdpi

【 摘 要 】

Recent developments in studies concerning cell-sized vesicles, such as liposomes with a lipid bilayer and water-in-oil droplets covered by a lipid monolayer, aim to realize the real-world modeling of living cells. Compartmentalization with a membrane boundary is essential for the organization of living systems. Due to the relatively large surface/volume ratio in microconfinement, the membrane interface influences phenomena related to biological functions. In this article, we mainly focus on the following subjects: (i) conformational transition of biopolymers in a confined space; (ii) molecular association on the membrane surface; and (iii) remote control of cell-sized membrane morphology.

【 授权许可】

CC BY   
© 2012 by the authors; licensee MDPI, Basel, Switzerland.