Materials | |
Cholesterol Organization in Phosphatidylcholine Liposomes: A Surface Plasmon Resonance Study | |
Kathryn A. Melzak2  Shirley A. Melzak2  Electra Gizeli1  | |
[1] Department of Biology, University of Crete and Institute of Molecular Biology and Biotechnology, F.O.R.T.H., 100 N. Plastira Street, Crete 70013, Greece; E-Mail:;Department of Nanobiotechnology, Institute for Biophysics, University of Natural Resources and Life Sciences Vienna (BOKU), Muthgasse 11/ll, Vienna A-1190, Austria; E-Mails: | |
关键词: cholesterol; cyclodextrin; liposome; membrane; membrane lateral organisation; OPPC; POPC; solubility; superlattice; surface plasmon resonance; | |
DOI : 10.3390/ma5112306 | |
来源: mdpi | |
【 摘 要 】
Models for the organization of sterols into regular arrays within phospholipid bilayers have been proposed previously. The existence of such arrays in real systems has been supported by the fact that concentration-dependent sterol properties show discontinuities at the cholesterol mole fractions corresponding to regular lattice arrangements. Experimental results presented here are based on a surface plasmon resonance assay that was used to analyze rates of cyclodextrin-mediated removal of cholesterol from adsorbed liposomes at cholesterol mole fractions up to
【 授权许可】
CC BY
© 2012 by the authors; licensee MDPI, Basel, Switzerland.
【 预 览 】
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RO202003190040277ZK.pdf | 743KB | download |