Efficient Preparation of α-Ketoacetals

Molecules

Francisco Ayala-Mata¹  Citlalli Barrera-Mendoza¹  Hugo A. Jiménez-Vázquez¹  Elena Vargas-D໚z¹ 

[1] id="af1-molecules-17-13864">Departamento de Química Orgánica, Escuela Nacional de Ciencias Biológicas del IPN, Prol. de Carpio y Plan de Ayala S/N, Col. Santo Tomás, Deleg. Gustavo A. Madero, México, DF 11340, Mexi

关键词: α;    α-dimethoxyacids;    Weinreb amide;    Grignard reagents;    α-ketoacetals;    salbutamol;   

DOI  :  10.3390/molecules171213864

来源: mdpi

【 摘 要 】

The Weinreb amides 2a,b were prepared from the α,α-dimethoxyacetic acids 1c,d. A number of representative nucleophilic additions (RMgX and RLi) on 2 afforded α-ketoacetals 3a–j in 70–99% yield. These compounds represent a versatile arrangement of functional groups of significant synthetic value, as demonstrated in the synthesis of (±)-salbutamol.

【 授权许可】

CC BY   
© 2012 by the authors; licensee MDPI, Basel, Switzerland.