Mouse Models for Efficacy Testing of Agents against Radiation Carcinogenesis—A Literature Review

International Journal of Environmental Research and Public Health

Leena Rivina¹ 

[1] Department of Environmental Health Sciences, University of California, Los Angeles, 650 Charles E. Young Dr. South, CHS 71-295, Los Angeles, CA 90095, USA

关键词: radiation carcinogenesis;    animal models;    radiation protectors;    radiation mitigators;    secondary cancers;   

DOI  :  10.3390/ijerph10010107

来源: mdpi

【 摘 要 】

As the number of cancer survivors treated with radiation as a part of their therapy regimen is constantly increasing, so is concern about radiation-induced cancers. This increases the need for therapeutic and mitigating agents against secondary neoplasias. Development and efficacy testing of these agents requires not only extensive in vitro assessment, but also a set of reliable animal models of radiation-induced carcinogenesis. The laboratory mouse (Mus musculus) remains one of the best animal model systems for cancer research due to its molecular and physiological similarities to man, small size, ease of breeding in captivity and a fully sequenced genome. This work reviews relevant M. musculus inbred and F₁ hybrid animal models and methodologies of induction of radiation-induced leukemia, thymic lymphoma, breast, and lung cancer in these models. Where available, the associated molecular pathologies are also included.

【 授权许可】

CC BY   
© 2013 by the authors; licensee MDPI, Basel, Switzerland.