Chemical Constituents from Andrographis echioides and Their Anti-Inflammatory Activity

International Journal of Molecular Sciences

De-Yang Shen⁴  Shin-Hun Juang¹  Ping-Chung Kuo³  Guan-Jhong Huang⁵  Yu-Yi Chan²  Amooru G. Damu⁴ 

[1] Graduate Institute of Pharmaceutical Chemistry, China Medical University, No. 91, Hsueh-Shih Road, Taichung 40402, Taiwan; E-Mail:;Department of Biotechnology, Southern Taiwan University of Science and Technology, Tainan 71005, Taiwan; E-Mail:;Department of Biotechnology, National Formosa University, Yunlin 632, Taiwan; E-Mail:;Department of Chemistry, National Cheng Kung University, Tainan 70101, Taiwan; E-Mail:;Department of Pharmacy, China Medical University, Taichung 40402, Taiwan; E-Mail:

关键词: Andrographis echioides;    flavonoid;    anti-inflammatory;    iNOS;   

DOI  :  10.3390/ijms14010496

来源: mdpi

【 摘 要 】

Phytochemical investigation of the whole plants of Andrographis echioides afforded two new 2′-oxygenated flavonoids (1) and (2), two new phenyl glycosides (3) and (4), along with 37 known structures. The structures of new compounds were elucidated by spectral analysis and chemical transformation studies. Among the isolated compounds, (1–2) and (6–19) were subjected into the examination for their iNOS inhibitory bioactivity. The structure-activity relationships of the flavonoids for their inhibition of NO production were also discussed.

【 授权许可】

CC BY   
© 2013 by the authors; licensee Molecular Diversity Preservation International, Basel, Switzerland.