Gene Expression and Regulation in Adrenocortical Tumorigenesis

Biology

Annabelle L. Fonseca¹  James Healy¹  John W. Kunstman¹  Reju Korah² 

[1]Department of Surgery, Yale Endocrine Neoplasia Laboratory, Yale University School of Medicine, 333 Cedar Street, TMP202 Box 208062, New Haven, CT 06520, USA

[2] E-Mails:

[3]Yale Endocrine Neoplasia Laboratory, Yale University School of Medicine, New Haven, CT 06520, USA

[4] E-Mail:

关键词: adrenocortical tumor;    epigenetics;    gene expression;    genetics;   

DOI  :  10.3390/biology2010026

来源: mdpi

【 摘 要 】

Adrenocortical tumors are frequently found in the general population, and may be benign adrenocortical adenomas or malignant adrenocortical carcinomas. Unfortunately the clinical, biochemical and histopathological distinction between benign and malignant adrenocortical tumors may be difficult in the absence of widely invasive or metastatic disease, and hence attention has turned towards a search for molecular markers. The study of rare genetic diseases that are associated with the development of adrenocortical carcinomas has contributed to our understanding of adrenocortical tumorigenesis. In addition, comprehensive genomic hybridization, methylation profiling, and genome wide mRNA and miRNA profiling have led to improvements in our understanding, as well as demonstrated several genes and pathways that may serve as diagnostic or prognostic markers.

【 授权许可】

CC BY   
© 2013 by the authors; licensee MDPI, Basel, Switzerland.