Cross-Coupling Reaction with Lithium Methyltriolborate

Molecules

Yasunori Yamamoto¹  Kazuya Ikizakura¹  Hajime Ito¹ 

[1] ¹Frontier Chemistry Center, Faculty of Engineering, Hokkaido University, Sapporo 060-8628, Japan ²Division of Chemical Process Engineering, Faculty of Engineering, Hokkaido University, Sapporo 060-8628, Japan

关键词: cross-coupling reaction;    palladium catalyst;    methyltrioolborate;   

DOI  :  10.3390/molecules18010430

来源: mdpi

【 摘 要 】

We newly developed lithium methyltriolborate as an air-stable white solid that is convenient to handle. The good performance of this triolborate for metal-catalyzed bond-forming reactions was demonstrated in palladium-catalyzed cross-coupling reactions with haloarenes. Cross-coupling reaction of [MeB(OCH₂)₃CCH₃]Li with aryl halides occurred in the presence of Pd(OAc)₂/RuPhos complex in refluxing MeOH/H₂O and the absence of bases.

【 授权许可】

CC BY   
This is an open access article distributed under the Creative Commons Attribution License (CC BY) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.